Implements the Genomic Random Interval (GRIN) framework for
identifying genomic loci affected by genomic lesions more frequently than
expected by chance. Supports multiple lesion classes, lesion constellation
analysis, exon-level target-size modeling, genomic lesion visualization,
and gene-level association analyses linking genomic lesions or gene
expression with binary and time-to-event clinical outcomes. Includes tools
for retrieving versioned GRCh38 Ensembl gene, exon, and regulatory-element
annotations. The statistical framework is described in Pounds et al. (2013)
<doi:10.1093/bioinformatics/btt372>.
| Version: |
2.1.0 |
| Depends: |
R (≥ 4.2.0) |
| Imports: |
circlize, data.table, dplyr, forcats, ggplot2, graphics, grDevices, grid, magrittr, stats, survival, tibble, tools, utils, writexl |
| Suggests: |
AnnotationHub, biomaRt, ComplexHeatmap, ensembldb, GenomeInfoDb, GenomicRanges, gridExtra, gridGraphics, Gviz, IRanges, knitr, rmarkdown, S4Vectors |
| Published: |
2026-08-22 |
| DOI: |
10.32614/CRAN.package.GRIN2 |
| Author: |
Abdelrahman Elsayed
 [aut, cre,
cph],
Xueyuan Cao [aut],
Lakshmi Anuhya Patibandla [aut],
Stanley Pounds [aut, cph] |
| Maintainer: |
Abdelrahman Elsayed <aelsayed at stjude.org> |
| BugReports: |
https://github.com/abdel-elsayed87/GRIN2/issues |
| License: |
GPL (≥ 3) |
| URL: |
https://github.com/abdel-elsayed87/GRIN2 |
| NeedsCompilation: |
no |
| Materials: |
NEWS |
| CRAN checks: |
GRIN2 results |