BKMutate: Statistical Analysis of Induced Mutagenesis Experiments in Crop
Plants
A colour-first toolkit for the statistical analysis of induced
mutagenesis experiments in crop plants. It fits dose-response models to
physical and chemical mutagen data and estimates the median lethal and
growth-reduction doses (LD50, GR50) with confidence intervals obtained
from Fieller's theorem; quantifies first-generation biological damage
(lethality, injury and pollen sterility); and estimates mutagenic
effectiveness and mutagenic efficiency. Effectiveness and efficiency are
conventionally reported as point estimates only; this package treats
them as functions of binomial proportions and supplies interval estimates
by the delta method on the logarithmic scale and by the nonparametric
bootstrap. It further provides chlorophyll mutation spectrum analysis with
tests of homogeneity and diversity, generalised linear models for
second-generation mutant counts with formal assessment of overdispersion,
and formal comparison of mutagens including relative biological
effectiveness. Every analysis returns a tidy result object and a
publication-ready 'ggplot2' figure. Methods follow Konzak et al. (1965,
ISBN:9789201150653), Fieller (1954) <doi:10.1111/j.2517-6161.1954.tb00159.x>
and Katz et al. (1978) <doi:10.2307/2530610>.
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